Job Type: Full-time Experience Required: 4+ years of relevant experience Location: Vibrant Sciences, 3100 N First Street, San Jose, CA About Us: Vibrant Sciences is a pioneering biotechnology company dedicated to developing innovative biological products. We are seeking a talented and experienced Senior Scientist to join our Cell Line Development team. Job Description As a Senior Scientist in Cell Line Development, you will play a crucial role in designing, developing, and optimizing cell lines for the production of biopharmaceuticals. You will be responsible for implementing cutting-edge technologies to enhance the efficiency, stability, and productivity of our cell lines. Key Responsibilities Design and execute cell line development strategies for the production of recombinant proteins, antibodies, and other biologics Implement and optimize transfection methods, selection processes, and cloning techniques Conduct genetic engineering using CRISPR/Cas9, ZFNs, or other genome editing tools Develop and apply high-throughput screening methods for clone selection Establish stable, high-expressing cell lines and evaluate their performance Characterize cell lines for productivity, stability, and product quality Collaborate with upstream and downstream process development teams Document experimental procedures, analyze data, and present findings Stay current with emerging technologies and scientific literature in the field Mentor junior scientists and contribute to a collaborative research environment Required Qualifications PhD in Cell Biology, Molecular Biology, Biochemistry, or related field Minimum 4 years of hands-on experience in mammalian cell line development Extensive experience with CHO, HEK293, or other mammalian expression systems Proficiency in molecular cloning, vector design, and genetic engineering Experience with cell line genetic characterization (qPCR, ddPCR, NGS) Strong knowledge of single-cell cloning techniques (FACS, limiting dilution, ClonePix) Experience with cell culture in various formats (shake flasks, bioreactors) Demonstrated track record of developing high-expressing, stable cell lines Excellent analytical, problem-solving, and troubleshooting skills Strong documentation and communication abilities Preferred Qualifications Experience with DOE (Design of Experiments) for process optimization Familiarity with regulatory requirements for cell line development Knowledge of automation platforms for high-throughput screening Experience with serum-free and chemically defined media development Familiarity with bioinformatics tools for sequence analysis and design Experience with process scale-up and tech transfer to manufacturing Seniority Level Mid-Senior level Employment Type Full-time #J-18808-Ljbffr Vibrant Sciences
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